Method for the production of amino terminus protected naturally occurring amino acids
US4822890A · kind A · utility
6Cited by
6References
9Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Jun 24, 1986 |
| Grant date | Apr 18, 1989 |
| Priority date | — |
| Expiry date | Jun 24, 2006 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C2603/18
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A method for the production of substantially 100% pure N.alpha.-urethane protected amino acids is disclosed. This method eliminates the formation of di-peptide and tri-peptide contaminants. Reaction of blocking reagents at the carboxylate site on a protected peptide is prevented by the application of labile amino acid esters. Subsequent removal of the ester yields, in ultra-high purity, the N.alpha.-protected amino acid. The substantially 100% pure N.alpha.-urethane protected amino acid are also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.