Enhancing drug delivery to the brain
US4835182A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Aug 21, 1987 |
| Grant date | May 30, 1989 |
| Priority date | — |
| Expiry date | Aug 21, 2007 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P35/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Tertiary butyl esters of anticancer drugs are provided which have the following formula: ##STR1## wherein R.sub.1 and R.sub.2 are the same or different and are selected from the group consisting of H, F, Cl, Br, and I and R.sub.2 can also be NH.sub.2 ; PA1 R.sub.3, R.sub.4, and R.sub.5 are the same or different and are selected from the group consisting of H, F, Cl, Br, I, and C.sub.1 -C.sub.3 alkyl; wherein alkyl may be substituted with F, Cl, Br, or I, with the proviso that at least two of R.sub.3, R.sub.4, and R.sub.5 are alkyl or substituted alkyl; and PA1 n=0-4. The compounds of the present invention can be used in treating cancer by significantly increasing the brain levels of the drugs of the invention and their active metabolites.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.