2,N.sup.6 -disubstituted and 2,N.sup.6 -trisubstituted adenosine-3'-phosphoramidites
US4845205A · kind A · utility
483Cited by
8References
6Claims
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Key dates
| Filing date | Jan 8, 1986 |
| Grant date | Jul 4, 1989 |
| Priority date | — |
| Expiry date | Jan 8, 2006 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q1/68
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention concerns 2,N.sup.6 -disubstituted and 2,N.sup.6 -trisubstituted adenosine nucleosides in which the sugar component is substituted at position 3' or position 5' by a phosphite or phosphoramidite group of the formula: ##STR1## R.sub.1 representing a lower alkyl or --(CH.sub.2).sub.n --CN with n being an integer between 1 and 4, and X representing a halogen or an amine group. These nucleosides make it possible to prepare sequences of nucleotides usable, in particular, as probes in the field of analyses and biological extractions.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.