Recombinant gamma interferons having enhanced stability and methods therefor
US4855238A · kind A · utility
40Cited by
5References
13Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Feb 27, 1984 |
| Grant date | Aug 8, 1989 |
| Priority date | — |
| Expiry date | Feb 27, 2004 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S930/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to novel, stable recombinant gamma interferons exhibiting in greater or less degree the antiviral and antiproliferative activity in humans and pH 2 labile properties characteristic of native human gamma interferon. The amino acid sequence of such an interferon comprises, from the N terminus: ##STR1## wherein X is a methionine residue or hydrogen and Y is a glutamine residue or, where X is hydrogen, Y is either a glutamine or a pyroglutamate residue.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.