Antihypertensive combination products containing a dihydropyridine and a pyridazodiazepine

US4859665A · kind A · utility

Assignees

• Hoffmann-La Roche Inc. · US
• Bayer Akt. · DE

Inventors

• Bernward Garthoff · Hilden, DE
• Marcel Gerold · Binningen, CH
• Fridolin Hefti · Allschwil, CH
• Stanislav Kazda · Wuppertal, DE
• Andreas Knorr · Erkrath, DE

Key dates

• Filing date: Dec 2, 1986
• Grant date: Aug 22, 1989
• Expiry date: Dec 2, 2006

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P9/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compositions for treating hypertension comprising an effective amount of a dihydropyridine of the formula ##STR1## in which X is 1 or 2 identical or different substituents from the group consisting of nitro, chlorine and trifluoromethyl, or together with the phenyl ring, the group ##STR2## R.sup.1 is alkyl of 1 to 4 C atoms, which is optionally substituted by alkoxy of 1 to 4 C atoms, PA1 R.sup.2 is alkyl of 1 to 12 C atoms, which is optionally substituted by alkoxy of 1 to 3 C atoms, fluorine or N-methyl-N-benzylamino and PA1 R.sup.3 is alkyl of 1 to 4 C atoms, cyano or hydroxymethyl, and a pyridazodiazepine of the formula ##STR3## in which R.sup.4 is aralkyl, PA1 R.sup.5 is hydrogen or alkyl of 1 to 8 C atoms, PA1 R.sup.6 is hydrogen or alkyl of 1 to 8 C atoms and PA1 R.sup.7 and R.sup.8 are hydrogen, or together, an oxo group, are described.