Synthesis of camptothecin and analogs thereof
US4894456A · kind A · utility
93Cited by
4References
12Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 31, 1987 |
| Grant date | Jan 16, 1990 |
| Priority date | — |
| Expiry date | Mar 31, 2007 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D491/22
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A method for synthesizing camptothecin and camptothecin analogs using a novel hydroxyl-containing tricyclic intermediate and the camptothecin analogs produced by the process. The camptothecin analogs are effective inhibitors of topoisomerase I and show anti-leukemic and anti-tumor activity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.