CDNA clone encoding brain amyloid of alzheimer's disease
US4912206A · kind A · utility
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3Claims
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Key dates
| Filing date | Feb 26, 1987 |
| Grant date | Mar 27, 1990 |
| Priority date | — |
| Expiry date | Feb 26, 2007 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K14/4711
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Four clones have been isolated from an adult human brain cDNA library using an oligonucleotide probe corresponding to the first 20 amino acids of the brain amyloid polypeptide of the Alzheimer's disease. The open reading frame of the sequenced clone coded for 97 amino acids including the known amino acid sequence of this polypeptide. The 3.5 kb messenger RNA has been detected in mammalian brains and human thymus. The gene is highly conserved in evolution and been mapped to human chromosome 21.
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