Alpha factor leader sequence directed secretion of insulin
US4914026A · kind A · utility
23Cited by
3References
15Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 23, 1986 |
| Grant date | Apr 3, 1990 |
| Priority date | — |
| Expiry date | Oct 23, 2006 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/75
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Methods and compositions are provided for efficient production of polypeptides having insulin activity. The proinsulin gene is joined to secretion and processing signals for expession and secretion in yeast. The product may be obtained in enhanced yield in the nutrient medium. Cell line AB103(PYinsl) was deposited at the A.T.C.C. on Apr. 6, 1983 and given Accession No. 20,670.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.