Vaccine against rotavirus diseases and method of preparing same

US4927628A · kind A · utility

Assignee

• The United States of America, as represented by the Department of Health and Human Services · US

Inventors

• Robert M. Chanock · Bethesda, US
• Albert Z. Kapikian · Rockville, US
• Karen Midthun · Sharpsburg, US
• Jorge Flores · Bethesda, US
• Mario Gorziglia · Silver Spring, US
• Yasutaka Hoshino · Wheaton, US
• Irene Peres-Schael · San José, VE

Key dates

• Filing date: Sep 21, 1987
• Grant date: May 22, 1990
• Expiry date: Sep 21, 2007

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S435/948
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A new method for producing live, attenuated rotavirus strains suitable for preparing a vaccine is described. It is demonstrated that a naturally attenuated rotavirus recovered from newborns or other individuals whos have undergone asymptomatic infection can be used for immunization or that a virulent rotavirus can be converted into an attenuated strain by substituting the conserved fourth rotavirus gene segments of a naturally attenuated rotavirus in the genome of the virulent rotavirus.