Water soluble prodrugs of camptothecin
US4943579A · kind A · utility
105Cited by
16References
3Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 6, 1987 |
| Grant date | Jul 24, 1990 |
| Priority date | — |
| Expiry date | Oct 6, 2007 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K47/555
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Water-soluble derivatives of camptothecin have the formulae: ##STR1## wherein R' is selected from the group consisting of R=CO CH.sub.2 NH.sub.2.HCl PA1 R=CO CH.sub.2 NHCH.sub.3.HCl PA1 R=CO CH.sub.2 NHC.sub.2 H.sub.5.HCl PA1 R=CO CH.sub.2 N(C.sub.2 H.sub.5).sub.2.HCl PA1 R=CO CH(NH.sub.2) CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 NH.sub.2.2HCl PA1 R=CO CH(NH.sub.2) CH.sub.2 CH.sub.2 COOH. HCl PA1 R=CO CH.sub.2 CH.sub.2.COO.sup.- Na.sup.+ PA1 R=HPO.sub.3.sup.- Na.sup.+
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.