Pyridine di-mevalono-lactones as inhibitors of cholesterol biosynthesis
US4950675A · kind A · utility
20Cited by
0References
7Claims
0Family size
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Key dates
| Filing date | Dec 21, 1988 |
| Grant date | Aug 21, 1990 |
| Priority date | — |
| Expiry date | Dec 21, 2008 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D405/14
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Certain trans-6,6'-[[(substituted)pyridin-3,5-diyl]-dialkane- and dialkene-diyl]bis [tetrahydro-4-hydroxypyran]-2-ones and the corresponding ring-opened acids derived therefrom are potent inhibitors of the enzyme 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase (HMG-CoA reductase) and are useful as hypocholesterolemic and hypolipidemic agents.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.