Transglutaminase inhibitors
US4970297A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Mar 13, 1987 |
| Grant date | Nov 13, 1990 |
| Priority date | — |
| Expiry date | Mar 13, 2007 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention is directed to compounds of the formula: ##STR1## or an optical isomer thereof, or a pharmaceutically acceptable salt thereof, wherein: n is 0, 1 or 2; p and q are independently 0, 1 or 2 and the sum of (p+q) is less than or equal to 3; X is selected from the group consisting of: halo; --OR.sup.2, --SR.sup.2, --S(O)R.sup.2, --S(O).sub.2 R.sup.2, and --S(O).sub.2 NHR.sup.2, wherein R.sup.2 is lower alkyl, mono-, di- or tri-fluoro alkyl of 2 or 3 carbon atoms, optionally substituted aryl; R is H or an N-protecting group; R.sup.1 is alkylthio, arylthio, amino, alkylamino, optionally substituted arylamino, or optionally substituted aralkylamino; and when the sum of n+p+q is greater than or equal to one, R.sup.1 is also hydroxy, alkoxy, or aralkoxy; and each (aa) is independently an .alpha.-amino acid residue with an optionally protected amino acid side chain.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.