Preparation of (threo)-1-aryl-2-acylamido-3-fluoro-1-propanols
US4973750A · kind A · utility
14Cited by
6References
7Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 23, 1989 |
| Grant date | Nov 27, 1990 |
| Priority date | — |
| Expiry date | Jan 23, 2009 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D303/34
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A novel sequence of highly selective chemical reactions for conversion of 3-Aryl-2-propyn-1-ols into cis-1-Aryl-3-fluoro-1-propene and into D,L-(threo)-1-Aryl-2-acylamido-3-fluoro-1-propanols is disclosed. Preparation of D-(threo)-1-Aryl-2-acylamido-3-fluoro-1-propanol antibacterial agents including the D-(threo)-3-fluoro-3-deoxy derivatives of chloramphenicol and thiamphenicol is also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.