Heteroarotinoids as anticancer agents

US4977276A · kind A · utility

Assignee

• The Board of Regents for the Oklahoma Agricultural and Mechanical Colleges acting for and on behalf of Oklahoma State Univ. · US

Inventors

• Kenneth D. Berlin · Stillwater, US
• Warren T. Ford · Stillwater, US
• Shirish N. Rajadhyaksha · Stillwater, US
• Jonathan B. Gale · Townsend, US
• Lyle W. Spruce · Chula Vista, US

Key dates

• Filing date: Dec 28, 1989
• Grant date: Dec 11, 1990
• Expiry date: Dec 28, 2009

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D409/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Novel heteroarotinoid compositions characterized by the formulae: ##STR1## where: X is S or O; OAc is the acetate group ##STR2## and R is --H, --OH, --OCH.sub.3, or --OC.sub.2 H.sub.5 and includes ##STR3## for formulae (1) and (2). Such compositions exhibit activity as anticancer agents.