Inventor · Chula Vista, CA, US

Lyle W. Spruce

36Patents
14h-index
29Co-inventors
77Inventor score

Filing activity: May 11, 1987 → Aug 24, 2005

Most-cited inventions

PatentTitleAreaCited byStatus
US5861380A Serine protease inhibitors-keto and di-keto containing ring systems Human Necessities 77 Expired
US6004933A Cysteine protease inhibitors Emerging Cross-Sectional Technologies 70 Expired
US6159938A Serine protease inhibitors comprising .alpha.-keto heterocycles Emerging Cross-Sectional Technologies 67 Expired
US5618792A Substituted heterocyclic compounds useful as inhibitors of (serine proteases) human neutrophil elastase Human Necessities 36 Expired
US5843900A Bradykinin antagonists Emerging Cross-Sectional Technologies 22 Expired
US5869455A Serine protease inhibitors-N-substituted derivatives Human Necessities 21 Expired
US6075120A Bradykinin antagonist Human Necessities 17 Expired
US6515003B1 Heterocyclic derivatives for the treatment of diabetes and other diseases Chemistry; Metallurgy 16 Expired
US5801148A Serine protease inhibitors-proline analogs Human Necessities 16 Expired
US6765013B2 Thiazolidinedione derivatives for the treatment of diabetes and other diseases Chemistry; Metallurgy 15 Expired
US4977276A Heteroarotinoids as anticancer agents Chemistry; Metallurgy 15 Expired
US5807829A Serine protease inhibitor--tripeptoid analogs Human Necessities 15 Expired
US5863899A Bradykinin antagonists Human Necessities 15 Expired
US6001814A Serine protease inhibitors Human Necessities 14 Expired
US6015791A Serine protease inhibitors-cycloheptane derivatives Human Necessities 14 Expired
US6001813A Val-pro containing .alpha.-keto oxadiazoles as serine protease inhibitors Human Necessities 14 Expired
US5874585A Substituted heterocyclic compounds useful as inhibitors of (serine proteases) human neutrophil elastase Human Necessities 12 Expired
US6037325A Substituted heterocyclic compounds useful as inhibitors of (serine proteases) human neutrophil elastase Human Necessities 9 Expired
US4833254A Heteroarotinoids as anticancer agents Chemistry; Metallurgy 8 Expired
US6001811A Serine protease inhibitors--N-substituted derivatives Human Necessities 8 Expired
US5891852A Serine protease inhibitors-cycloheptane derivatives Human Necessities 8 Expired
US5214191A Oxidant sensitive and insensitive aromatic esters as inhibitors of human neutrophil elastase Chemistry; Metallurgy 8 Expired
US7153875B2 Heterocyclic derivatives for the treatment of cancer and other proliferative diseases Chemistry; Metallurgy 8 Expired
US5663416A Oxidant sensitive and insensitive aromatic esters as inhibitors of human neutrophil elastase Chemistry; Metallurgy 7 Expired
US6100238A Indole and tetrahydroisoquinoline containing Alpha-keto oxadiazoles as serine protease inhibitors Human Necessities 6 Expired

Source: USPTO / EPO open patent data. Inventor disambiguation is heuristic; counts are objective bibliographic measures.