Protected nucleosides which permit more efficient oligonucleotide syntheses
US4980460A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Mar 30, 1987 |
| Grant date | Dec 25, 1990 |
| Priority date | — |
| Expiry date | Mar 30, 2007 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H21/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention relates to derivatives of nucleosides and their use for the synthesis of oligonucleotides. These derivatives are in accordance with the formula: ##STR1## in which B represents a radical derived from guanine, cytosine or adenine, whose exocylic NH group is protected by the group ##STR2## with R.sup.1 representing a hydrogen atom or an alkyl radical and R.sup.2 a hydrogen atom, and alkyl radical, an alkoxy radical and optionally substituted aryloxy radical, R.sup.3 represents a hydrogen atom, the dimethoxytrityl radical or the radical ##STR3## R.sup.4 represents a hydrogen atom, the radical of formula: ##STR4## or a radical suitable for the synthesis of polynucleotides and R.sup.5 represents a hydrogen atom or the protected or unprotected hydroxyl OH radical.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.