7-substituted derivatives of 2-amino-3H,5H-pyrrolo(3,2-d)pyrimidin-4-ones and pharamceutical uses and compositions containing the same

US4985434A · kind A · utility

Assignee

• BioCryst, Inc. · US

Inventors

• John A. Secrist, III · Birmingham, US
• John A. Montgomery · Birmingham, US
• Steve E. Ealick · Birmingham, US
• Mark D. Erion · Del Mar, US
• Wayne Charles Guida · Fanwood, US

Key dates

• Filing date: Oct 31, 1989
• Grant date: Jan 15, 1991
• Expiry date: Oct 31, 2009

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Disclosed is a compound containing 2-amino-7-(R)-3H,5H-pyrrolo[3,2-d]pyrimidin-4-one wherein R is optionally substituted cyclohexenyl or cyclohexyl, a pharmaceutical composition containing the compound, and a method for the selective suppresion of mammalian T-cell function without diminished effect on humoral immunity which involves administering the composition to a mammal.