Enhanced expression of human interleukin-2 in mammalian cells
US4992367A · kind A · utility
12Cited by
3References
11Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | May 12, 1986 |
| Grant date | Feb 12, 1991 |
| Priority date | — |
| Expiry date | May 12, 2006 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2800/108
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods and compositions are provided for the high level expression of human interleukin-2 in mammalian cells. This high level expression is produced by the substitution of the normal human 5' noncoding sequences and the AUG initiation codon of the interleukin-2 gene by heterologous corresponding sequences. The expression product is a glycosylated polypeptide which is similar to the natural product and which can be purified to a high degree of purity for use as a therapeutic agent.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.