2-amino-7-(heterocyclomethyl)-3H,5H-pyrrolo[3,2-d]pyrimidin-4-ones and pharmaceutical uses and compositions containing the same

US5008270A · kind A · utility

Assignee

• BioCryst, Inc. · US

Inventors

• John A. Secrist, III · Birmingham, US
• John A. Montgomery · Birmingham, US
• Steve E. Ealick · Birmingham, US
• Mark D. Erion · Del Mar, US
• Wayne Charles Guida · Fanwood, US

Key dates

• Filing date: Oct 31, 1989
• Grant date: Apr 16, 1991
• Expiry date: Oct 31, 2009

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D207/34
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Disclosed is a compound containing a 2-amino-7-(substituted methyl)-3H,5H-pyrrolo[3,2-d]pyrimidin-4-one wherein substituted methyl is --CH.sub.2 --R wherein R is an optionally substituted heteroalicyclic group, a pharmaceutical composition containing the compound, and a method for the selective suppression of mammalian T-cell function without diminished effect on humoral immunity which involves administering the composition to a mammal.