Rapamycin oximes
US5023264A · kind A · utility
146Cited by
6References
9Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jul 16, 1990 |
| Grant date | Jun 11, 1991 |
| Priority date | — |
| Expiry date | Jul 16, 2010 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H19/01
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A derivative of rapamycin in which the 27-position has the structure ##STR1## wherein R.sup.1 is hydrogen, alkyl, or --CH.sub.2 Ar; PA1 Ar is ##STR2## wherein R.sup.2, R.sup.3, and R.sup.4 are each, independently, hydrogen, alkyl, aralkyl, alkoxy, hydroxy, cyano, halo, nitro, carbalkoxy, trifluoromethyl, amino, or a carboxylic acid; PA1 X is N, O, or S; or a pharmaceutically acceptable salt thereof, which is by virtue of its immunosuppresive activity is useful in treating transplantation rejection host vs. graft disease, autoimmune diseases, and diseases of inflammation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.