Horizontal flow-through coil planet centrifuge with multilayer plural coils in eccentric synchronous rotation, suitable for counter-current chromatography
US5024758A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Mar 19, 1990 |
| Grant date | Jun 18, 1991 |
| Priority date | — |
| Expiry date | Mar 19, 2010 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N30/42
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A horizontal flow-through coil centrifuge provides a very long continuous partition facilitating passage through a plurality of serially connected multilayer helical tubing coils subjected to a rotary motion at a selected angular velocity about a column assembly axis and, simultaneously, a revolving motion of that axis about a stationary horizontal axis at the same angular velocity therearound. The passage of a fluid mobile phase containing solute through the very long length of tubing generates a commensurately long dwell time of the solutes in the complex gravitational/centrifugal acceleration field through a relatively large volume of a fluid stationary phase held in the moving tubing, thus enabling very sensitive chromatographic separations of constituents between the two fluid phases. Gearing and speed and temperature controls are provided in the apparatus to ensure that inflow/outflow tubing remains free of twisting and allowing use at a variety of operational speeds and fluid temperatures.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.