Treatment of human retroviral infections with 2',3'-dideoxyinosine alone and in combination with other antiviral compounds

US5026687A · kind A · utility

Assignee

• The United States of America, as represented by the Department of Health and Human Services · US

Inventors

• Robert Yarchoan · Bethesda, US
• Hiroaki Mitsuya · Rockville, US
• Samuel Broder · Weston, US

Key dates

• Filing date: Jan 3, 1990
• Grant date: Jun 25, 1991
• Expiry date: Jan 3, 2010

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P31/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A preferred method and dosages for the short and long-term treatment of human retroviral infections, or retroviral-like infections, including acquired immunodeficiency syndrome (AIDS) and other manifestations of human immunodeficiency virus (HIV) infection, with 2',3'-dideoxyinosine (ddl) are disclosed, along with a protocol for halting and restarting 2',3'-dideoxyinosine to minimize certain side effects.