Octahydrobenzo(f)quinoline derivatives
US5030636A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Mar 13, 1990 |
| Grant date | Jul 9, 1991 |
| Priority date | — |
| Expiry date | Mar 13, 2010 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P25/18
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Compounds of the formula ##STR1## wherein R.sup.1 is hydrogen; lower-alkyl, unsubstituted or substituted by hydroxy, lower-alkoxy, cyano, halogen, lower-alkoxycarbonyl, aminocarbonyl, substituted benzoyl or substituted .alpha.-hydroxybenzyl; lower-alkenyl; cycloalkyl; cycloalkyl-lower-alkyl; heteroaryl-lower-alkyl; or aryl-lower-alkyl, unsubstituted or substituted by hydroxy, lower-alkoxy, lower-alkyl or halogen, and R.sup.2 is hydrogen or lower-alkanoyl, PA0 in the form of the racemates and the optical antipodes as well as pharmaceutically acceptable acid addition salts thereof which are active as selective, presynaptically-acting dopamine receptor agonists and are accordingly suitable for the control or prevention of central nervous system illnesses, especially for the control or prevention of psychotic disorders such as chronic schizophrenia, are described. The compounds of formula I can be prepared according to various methods which are known.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.