Method for identifying or shielding functional sites or epitopes of proteins that enter the exocytotic pathway of eukaryotic cells, the mutant proteins so produced and genes encoding said mutant proteins
US5041376A · kind A · utility
73Cited by
0References
6Claims
0Family size
Assignees
Inventors
Key dates
| Filing date | Dec 9, 1988 |
| Grant date | Aug 20, 1991 |
| Priority date | — |
| Expiry date | Dec 9, 2008 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2760/16022
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention relates to a method for identifying or shielding functional sites or epitopes of proteins that enter the exocytotic pathway of eukaryotic cells (transportable proteins) by the addition of supernumerary N-linked oligosaccharide side chains at chosen sites on the surface thereof using oligonucleotide mutagenesis. The present invention also relates to mutant transportable proteins having supernumerary N-linked oligosaccharide side chains which shield functional sites or epitopes; and genes which encode the same.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.