Method and nucleic acid for the preparation of lecithin:cholesterol acyltransferase
US5049488A · kind A · utility
7Cited by
3References
4Claims
0Family size
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Key dates
| Filing date | Nov 8, 1985 |
| Grant date | Sep 17, 1991 |
| Priority date | — |
| Expiry date | Nov 8, 2005 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S435/803
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Nucleic acid encoding lecithin:cholesterol acyltransferase is ligated into expression vectors and used to transform host cells for the synthesis of lecithin:cholesterol acyltransferase in recombinant cell culture. Lecithin:cholesterol acyltransferase amino acid sequence variants are described for enhancing the properties of lecithin:cholesterol acyltransferase. Lecithin:cholesterol acyltransferase and its variants are employed in the therapy of conditions characterized by hypercholesterolemia and for the mobilization of cholesterol in vivo.
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