Qunoline intermediates useful therein for synthesizing antibacterial compounds
US5066800A · kind A · utility
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7Claims
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Assignee
Inventor
Key dates
| Filing date | Apr 27, 1990 |
| Grant date | Nov 19, 1991 |
| Priority date | — |
| Expiry date | Apr 27, 2010 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P31/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A novel process and intermediates used therein for linking a cephalosporin compound to a quinolone are disclosed. According to the disclosed process, the 2-carboxylic acid moiety of the cephalosporin compound is treated with an organic base. The resulting salt is then reacted with a quinolone compound which has been activated using a haloformate. The reaction is run in a non-aqueous organic solvent. 4-Dimethylaminopyridine is used to promote the reaction between the cephalosporin salt and the activated quinolone.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.