4,5,7,8-tetrahydro-6H-thiazolo[5,4-d]azepines, their preparation and their use as pharmaceutical compositions

US5068325A · kind A · utility

Assignee

• Karl Thomae GmbH · DE

Inventors

• Wolfgang Grell · Biberach, DE
• Rudolf Hurnaus · Großenhain, DE
• Manfred Reiffen · Biberach, DE
• Robert Sauter · Biberach, DE
• Ludwig Pichler · Wien, AT
• Walter Kobinger · Wien, AT
• Michael Entzeroth · Warthausen, DE
• Joachim Mierau · Mainz, DE
• Gunter Schingnitz · Bad Kreuznach, DE

Key dates

• Filing date: Jun 20, 1989
• Grant date: Nov 26, 1991
• Expiry date: Jun 20, 2009

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P25/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to new 4,5,7,8-tetrahydro-6H-thiazolo[5,4-d]azepines of general formula II ##STR1## wherein the substituents are defined herein below, which compounds have valuable pharmacological properties, namely selective effects on the dopaminergic system which are achieved by stimulating (predominantly D2) dopamine receptors.