Selectively cytotoxic IL-4-PE40 fusion protein

US5082927A · kind A · utility

Assignee

• The United States of America, as represented by the Department of Health and Human Services · US

Inventors

• Ira H. Pastan · Potomac, US
• David Fitzgerald · Rockville, US
• Masato Ogata · Kamakura, JP

Key dates

• Filing date: May 12, 1989
• Grant date: Jan 21, 1992
• Expiry date: May 12, 2009

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S530/825
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides a chimeric protein IL4-PE40 which selectively kills IL4 receptor bearing cells. A mutant form of the protein is also provided.