Human tissue plasminogen activator variants
US5094953A · kind A · utility
8Cited by
1References
3Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 21, 1988 |
| Grant date | Mar 10, 1992 |
| Priority date | — |
| Expiry date | Mar 21, 2008 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Y304/21069
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Disclosed are novel variants of tissue plasminogen activator (t-PA) that have surprising biological/pharmacokinetic properties compared with native t-PA. For example, certain of the variants hereof demonstrate increased half-life profiles, and show good fibrin binding activity even though fibrin binding regions of the molecule are deleted. All associated means and methods for preparing such variants recombinantly and for using such variants are also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.