Regioselective substitutions in cyclodextrins

US5096893A · kind A · utility

Assignee

• The United States of America, as represented by the Department of Health and Human Services · US

Inventors

• Josef Pitha · Baltimore, US
• Bengt Lindberg · Stockholm, SE

Key dates

• Filing date: Dec 17, 1990
• Grant date: Mar 17, 1992
• Expiry date: Dec 17, 2010

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C08B37/0012
• WIPO field: Macromolecular chemistry, polymers
• WIPO sector: Chemistry

Abstract

A method for obtaining a desired pattern of substitution of hydroxyalkyl groups on cyclodextrins which comprises controlling the basicity of a reaction mixture comprising epoxide and cyclodextrins and a suitable solvent. Through the proper control of basicity with, e.g., sodium hydroxide, hydroxyalkyl substitution may be directed either toward the narrow or wide opening of the cavity of cyclodextrins.