Camptothecin analogs as potent inhibitors of topoisomerase I
US5106742A · kind A · utility
65Cited by
6References
7Claims
0Family size
Inventors
Key dates
| Filing date | Oct 23, 1989 |
| Grant date | Apr 21, 1992 |
| Priority date | — |
| Expiry date | Oct 23, 2009 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D491/14
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method for synthesizing camptothecin and camptothecin analogs using a novel hydroxyl-containing tricyclic intermediate and the camptothecin analogs produced by the process. The camptothecin analogs are effective inhibitors of topoisomerase I and show anti-leukemic and anti-tumor activity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.