On-capillary gap junction for fluorescence detection in capillary electrophoresis
US5110431A · kind A · utility
36Cited by
3References
27Claims
0Family size
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Inventor
Key dates
| Filing date | Feb 28, 1990 |
| Grant date | May 5, 1992 |
| Priority date | — |
| Expiry date | Feb 28, 2010 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2030/8435
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A junction reactor that aligns a pair of capillaries substantially collinearly, end-to-end that allows a small gap to be produced between these two ends. An applied voltage difference between the other ends of these two capillaries produces in the gap electric field lines that extend across the gap. Empirical evidence shows that the gap introduces only a small reduction in resolution of an electrophoretic or electrochromatographic separation. The gap enables sample liquid to be coupled between capillaries of different internal diameters and enables on-capillary reactions such as attaching a fluorescent tag to a sample components.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.