Prazosin analog with increased selectivity and duration of action

US5110927A · kind A · utility

Assignee

• The United States of America, as represented by the Department of Health and Human Services · US

Inventors

• Josef Pitha · Baltimore, US
• John W. Kusiak · Lanham, US

Key dates

• Filing date: Dec 31, 1987
• Grant date: May 5, 1992
• Expiry date: Dec 31, 2007

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D409/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Alkylating analogs of prazosin were synthesized and found to compete with nanomolar potency at .sup.3 H-prazosin binding sites of rat tissues. The compounds were found to be irreversible ligands at .sup.3 H-prazosin binding sites, and denoted a subtype of alpha.sub.1 -adrenoceptors.