Method of synthesizing leukotriene B.sub.4 and derivatives thereof
US5110949A · kind A · utility
3Cited by
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1Claims
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Key dates
| Filing date | Sep 13, 1989 |
| Grant date | May 5, 1992 |
| Priority date | — |
| Expiry date | Sep 13, 2009 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F7/1804
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
An improved method for synthesizing leukotriene B.sub.4 and derivatives thereof is disclosed, as are novel intermediates used in the process. Unlike prior art processes, the method of this invention involves a step in which 2(R)-[[(1,1-dimethylethyl)diphenylsilyl]oxy]dec-4 (Z)-ene-1-ol or a related compound is coupled with methyl-[5(S)-[[1,1dimethylethyl)-diphenylsilyl]oxy]-dec-8 (E)-10-(dimethylphosphono)-6-ynoate.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.