Modified PF4 compositions and methods of use
US5112946A · kind A · utility
151Cited by
2References
18Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Jul 6, 1989 |
| Grant date | May 12, 1992 |
| Priority date | — |
| Expiry date | Jul 6, 2009 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The subject invention pertains to the use of modified PF4 and recombinant PF4(rPF4) as well as modified analogs (mutants) of PF4, and peptide fragments thereof, to inhibit angiogenesis. The modified PF4, analogs, and certain fragments are shown to have utility for treating angiogenic diseases and for the inhibition of endothelial cell proliferation. Also, the subject invention concerns modification of PF4 which facilitate the targeting of the biological activity of PF4 to specific locations.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.