Aminoesters of rapamycin
US5130307A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Feb 19, 1991 |
| Grant date | Jul 14, 1992 |
| Priority date | — |
| Expiry date | Feb 19, 2011 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A compound of the structure ##STR1## wherein R.sup.1 and R.sup.2 are each, independently, hydrogen or ##STR2## with the proviso that R.sup.1 and R.sup.2 are not both hydrogen; R.sup.3 is hydrogen, alkyl, aralkyl, --(CH.sub.2).sub.q CO.sub.2 R.sup.6,--(CH.sub.2).sub.r NR.sup.7 CO.sub.2 R.sup.8, carbamylalkyl, aminoalkyl, hydroxyalkyl, guanylalkyl, mercaptoalkyl, alkylthioalkyl, indolylmethyl, hydroxyphenyklmethyl, imidazoylmethyl or phenyl which is optionally mono-, di-, or tri-substituted with a sustituent selected from alkyl, alkoxy, hydroxy, cyano, halo, nitro, carbalkoxy, trifluoromethyl, amino, or a carboxylic acid; PA1 R.sup.4 and R.sup.7 are each, independently, hydrogen, alkyl, or aralkyl; PA1 R.sup.5, R.sup.6, and R.sup.8 are each, indpendently, alkyl, aralkyl, fluorenylmethyl, or phenyl which is optionally mono-, di-, or tri-substituted with a substituent selected from alkyl, alkoxy, hydroxy, cyano, halo, nitro, carbalkoxy, trifluoromethyl, amino, or a carboxylic acid; PA1 m is 0-4; PA1 n is 0-4; PA1 p is 1-2; PA1 q is 0-4; PA1 r is 0-4; wherein R.sup.3, R.sup.4, m, and n are independent in each of the ##STR3## subunits when p=2; or a pharmaceutically acceptable salt there…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.