2-hydroxypropylamino-alkyl-benzimidazoly-5-yl derivatives and their use in the treatment of heart disease

US5135932A · kind A · utility

Assignee

• Dr. Karl Thomae GmbH · DE

Inventors

• Norbert Hauel · Schemmerhofen, DE
• Annerose Mauz · Riedlingen, DE
• Jacques van Meel · Mittelbiberach, DE
• Michael Entzeroth · Warthausen, DE
• Rainer Zimmermann · Mittelbiberach, DE
• Willi Diederen

Key dates

• Filing date: May 30, 1990
• Grant date: Aug 4, 1992
• Expiry date: May 30, 2010

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D413/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to new 2-hydroxy-n-propylamines of the formula EQU R.sub.1 --O--CH.sub.2 --CHOH--CH.sub.2 --NH--A--R.sub.2 (I) wherein PA0 R.sub.1, R.sub.2 and A are defined as in claim 1, the tautomers, enantiomers and acid addition salts thereof, particularly for pharmaceutical use the physiologically acceptable acid addition salts thereof with inorganic or organic acids, which have valuable pharmacological properties, more particularly a simultaneous cardiotonic and .beta.-blocking activity, and the use thereof as pharmaceutical compositions and processes for preparing them.