Polyamine conjugated oligonucleotides
US5138045A · kind A · utility
585Cited by
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11Claims
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Assignee
Inventors
Key dates
| Filing date | Jul 27, 1990 |
| Grant date | Aug 11, 1992 |
| Priority date | — |
| Expiry date | Jul 27, 2010 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H21/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Oligonucleotide analogs are provided having improved cellular uptake and improved nuclease resistance. Modification of oligonucleotides through the attachment of nitrogenous moieties, especially polyamines, hydrazines and the like to nucleosidic portions of the analogs is disclosed. Oligonucleotides targeted at the tat region of HIV comprise certain preferred embodiments.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.