Patent assignee · US · COMPANY

Isis Pharmaceuticals, Inc.

1,054Patents
217Active
1,054Granted
52Portfolio score

Filing activity: Feb 26, 1990 → Feb 26, 2018 · 137 expiring within 5 years

Most-cited patents

PatentTitleAreaCited byStatus
US5602240A Backbone modified oligonucleotide analogs Chemistry; Metallurgy 921 Expired
US5801154A Antisense oligonucleotide modulation of multidrug resistance-associated protein Chemistry; Metallurgy 820 Expired
US5459255A N-2 substituted purines Chemistry; Metallurgy 758 Expired
US5489677A Oligonucleoside linkages containing adjacent oxygen and nitrogen atoms Chemistry; Metallurgy 722 Expired
US5519134A Pyrrolidine-containing monomers and oligomers Chemistry; Metallurgy 641 Expired
US5608046A Conjugated 4'-desmethyl nucleoside analog compounds Chemistry; Metallurgy 616 Expired
US5670633A Sugar modified oligonucleotides that detect and modulate gene expression Chemistry; Metallurgy 602 Expired
US5610289A Backbone modified oligonucleotide analogues Chemistry; Metallurgy 593 Expired
US5587361A Oligonucleotides having phosphorothioate linkages of high chiral purity Chemistry; Metallurgy 588 Expired
US5138045A Polyamine conjugated oligonucleotides Chemistry; Metallurgy 585 Expired
US5587469A Oligonucleotides containing N-2 substituted purines Chemistry; Metallurgy 574 Expired
US5681941A Substituted purines and oligonucleotide cross-linking Chemistry; Metallurgy 556 Expired
US5541307A Backbone modified oligonucleotide analogs and solid phase synthesis thereof Chemistry; Metallurgy 550 Expired
US5614617A Nuclease resistant, pyrimidine modified oligonucleotides that detect and modulate gene expression Emerging Cross-Sectional Technologies 547 Expired
US5623070A Heteroatomic oligonucleoside linkages Chemistry; Metallurgy 517 Expired
US5677437A Heteroatomic oligonucleoside linkages Chemistry; Metallurgy 501 Expired
US6107094A Oligoribonucleotides and ribonucleases for cleaving RNA Emerging Cross-Sectional Technologies 476 Expired
US5618704A Backbone-modified oligonucleotide analogs and preparation thereof through radical coupling Chemistry; Metallurgy 474 Expired
US7399845B2 6-modified bicyclic nucleic acid analogs Emerging Cross-Sectional Technologies 471 Active
US5386023A Backbone modified oligonucleotide analogs and preparation thereof through reductive coupling Chemistry; Metallurgy 464 Expired
US5646265A Process for the preparation of 2'-O-alkyl purine phosphoramidites Chemistry; Metallurgy 456 Expired
US5359044A Cyclobutyl oligonucleotide surrogates Chemistry; Metallurgy 442 Expired
US5218105A Polyamine conjugated oligonucleotides Chemistry; Metallurgy 438 Expired
US5539083A Peptide nucleic acid combinatorial libraries and improved methods of synthesis Performing Operations; Transporting 401 Expired
US5700922A PNA-DNA-PNA chimeric macromolecules Chemistry; Metallurgy 397 Expired

Source: USPTO / EPO open patent data. Counts and citation impact are objective bibliographic measures.