Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5143854A · kind A · utility
1,974Cited by
34References
13Claims
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Key dates
| Filing date | Mar 7, 1990 |
| Grant date | Sep 1, 1992 |
| Priority date | — |
| Expiry date | Mar 7, 2010 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T436/2575
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Polypeptide arrays can be synthesized on a substrate by attaching photoremovable groups to the surface of a substrate, exposing selected regions of the substrate to light to activate those regions, attaching an amino acid monomer with a photoremovable group to the activated regions, and repeating the steps of activation and attachment until polypeptides of the desired length and sequences are synthesized. The resulting array can be used to determine which peptides on the array can bind to a receptor.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.