Anti-bacterial cephalosporin compounds

US5147871A · kind A · utility

Assignee

• Hoffmann-La Roche Inc. · US

Inventors

• Harry A. Albrecht · Towaco, US
• Ka-Kong Chan · Hopatcong, US
• Dennis Keith · Montclair, US
• Rudolf Then · Weil, DE
• Manfred Weigele · North Caldwell, US

Key dates

• Filing date: Dec 5, 1991
• Grant date: Sep 15, 1992
• Expiry date: Dec 5, 2011

Classification

• Technology area (CPC B): Performing Operations; Transporting
• CPC primary: B82Y5/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

There are presented anti-bacterial cephalosporins having broad antimicrobial activity of the formula ##STR1## wherein R.sub.1 is an antibiotically active quinolonyl; R.sub.2 is selected from the group consisting of hydrogen, lower alkoxy, amino, lower alkylthio and amido; R.sub.3 is selected from the group consisting of hydrogen, and acyl group, and m is 0, 1 or 2 and the readily hydrolysable esters or salts of these compounds and hydrates of the compounds of formula I or of their esters or salts.