3-[2-[4-(6-fluoro-1,2-benzisoxozol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9 tetrahydro-9-hydroxy-2-methyl-4H-pyrido [1,2-a]pyrimidin-4-one, compositions and method of use

US5158952A · kind A · utility

Assignee

• Janssen Pharmaceutica NA · BE

Inventors

• Cornelus Gerardus Maria Janssen · Vosselaar, BE
• Alfonsus G. Knaeps · Herentals, BE
• Ludo Edmond Josephine Kennis · Lier, BE
• Jan Vandenberk · Beerse, BE

Key dates

• Filing date: Oct 17, 1989
• Grant date: Oct 27, 1992
• Expiry date: Oct 17, 2009

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to novel 3-piperidinyl-1,2-benzisoxazoles having long-acting antipsychotic properties and which are useful in the treatment of warm-blooded animals suffering from psychotic diseases. Methods of preparing said compounds and compositions containing the same.