Superoxide dismutase analogs having novel binding properties
US5171680A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Aug 1, 1990 |
| Grant date | Dec 15, 1992 |
| Priority date | — |
| Expiry date | Aug 1, 2010 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/33
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Superoxide dismutase (SOD) analogs whose amino acid sequence includes a heterologous peptide domain such as the RGDX tetrapeptide found in fibronectin or the LGGAKQAGDV decapeptide found in fibrinogen that enables the analog to bind to a moiety that is normally present at sites of desired SOD therapy. The domain is incorporated into the SOD sequence in a manner in which it is available to interact with such moieties but does not destroy the enzymatic activity of the molecule. The inclusion of the domain enables the analog to more readily access the target tissue upon which it is to act and/or increase the corporeal half-life of the molecule.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.