Preparation of specifically substituted cyclodextrins

US5173481A · kind A · utility

Assignee

• The United States of America, as represented by the Department of Health and Human Services · US

Inventors

• Josef Pitha · Baltimore, US
• C. Trinadha Rao · Ongole, IN
• Bengt Lindberg · Stockholm, SE

Key dates

• Filing date: Jun 28, 1990
• Grant date: Dec 22, 1992
• Expiry date: Jun 28, 2010

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C08B37/0012
• WIPO field: Macromolecular chemistry, polymers
• WIPO sector: Chemistry

Abstract

A process for producing monosubstituted alpha-, beta-, and gamma-cyclodextrins includes the step of condensing an excess of a cyclodextrin with an epoxide under alkaline conditions. A process for increasing the solubility of cyclodextrins includes the step of reacting a cyclodextrin with an amine under heterogenous catalytic conditions, or subjecting the cyclodextrin to sulfatation. Compositions useful in these processes include one containing at least one cyclodextrin, ammonia and Raney nickel, and a second composition containing at least one cyclodextrin, chlorosulfonic acid and pyridine.