Method for preparation of taxol using .beta.-lactam
US5175315A · kind A · utility
145Cited by
6References
3Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Sep 29, 1989 |
| Grant date | Dec 29, 1992 |
| Priority date | — |
| Expiry date | Sep 29, 2009 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A .beta.-lactam of the formula: ##STR1## wherein R.sub.1 is aryl, substituted aryl, alkyl, alkenyl, or alkynyl; R.sub.2 is hydrogen, alkyl, acyl, acetal, ethoxyethyl, or other hydroxyl protecting group; and R.sub.3 is aryl, substituted aryl, alkyl, alkenyl, or alkynyl; and process for the preparation of taxol comprising contacting said .beta.-lactam and an alcohol in the presence of an activating agent to provide a taxol intermediate, and converting the intermediate to taxol.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.