Use of binding protein with IGF-I as an anabolic growth promoting agent
US5187151A · kind A · utility
78Cited by
1References
17Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Feb 12, 1991 |
| Grant date | Feb 16, 1993 |
| Priority date | — |
| Expiry date | Feb 12, 2011 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method is disclosed for producing an anabolic state in a mammal by co-administration by subcutaneous injection of a combination of effective amounts of IGF-I and an IGF binding protein in a defined molar ratio in the absence of growth hormone so as to produce a greater anabolic response in the mammal than that achieved using IGF-I alone in an amount equal to that used for IGF-I in the combination. Preferably, the IGF-I is native-sequence, mature human IGF-I, the binding protein is IGFBP-3, and the mammal is human or a non-human animal of economic importance such as a cow or pig.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.