7-disubstituted-methyl-4-oxo-3H,5H-pyrrolo[3,2d]pyrimidine and pharmaceutical uses and compositions containing the same

US5189039A · kind A · utility

Assignee

• BioCryst, Inc. · US

Inventors

• Shri Niwas · Maple Grove, US
• John A. Secrist, III · Birmingham, US
• John A. Montgomery · Birmingham, US
• Mark D. Erion · Del Mar, US
• Wayne Charles Guida · Fanwood, US
• Steve E. Ealick · Birmingham, US

Key dates

• Filing date: May 14, 1991
• Grant date: Feb 23, 1993
• Expiry date: May 14, 2011

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Disclosed is a compound of the formula ##STR1## wherein R.sup.1 is H, NH.sub.2, or OCH.sub.3, R.sup.2 is an optionally substituted cyclic group optionally containing one or more heteroatoms, R.sup.3 and R.sup.4 are independently H or C.sub.1-4 alkyl, m is 0-4, n is 0-6, p is 0.1, X is CN, CSNH.sub.2, PO(OH).sub.2, COOH, SO.sub.2 NH.sub.2, NH.sub.2, OH, CNHNH.sub.2, tetrazole, triazole, or COR.sup.5 where R.sup.5 is C.sub.1-4 alkyl, CF.sub.3, NH.sub.2, or OC.sub.1-4 alkyl, and Y is O or NH that is useful as a pharmaceutical.