Hydrogen phosphonodithioate compositions
US5194599A · kind A · utility
226Cited by
6References
10Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 23, 1988 |
| Grant date | Mar 16, 1993 |
| Priority date | — |
| Expiry date | Sep 23, 2008 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H19/20
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Novel hydrogen-phosphonodithioate compositions are provided which are particularly useful for forming internucleotide and internucleoside linkages in oligonucleosides or oligonucleotides. The oligonucleotides and analogs thereof made by using the hydrogen-phosphonodithioate compositions may be therapeutically useful as antiviral and anticancer agents and may have other therapeutic or diagnostic uses. A method for making the hydrogen-phosphonodithioates is provided as well as a method for converting same to an activated intermediate for substitution on the phosphorus atom.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.