5-aminocarbonyl-5H-dibenzo[a.d]cyclohepten-5,10-imines for treatment of epilepsy and cocaine addiction

US5196415A · kind A · utility

Assignee

• The United States of America, as represented by the Department of Health and Human Services · US

Inventors

• James Allen Monn · Indianapolis, US
• Andrew Thurkauf · Danbury, US
• Shunichi Yamaguchi · Bethesda, US
• Michael A. Rogawski · Sacramento, US
• Kenner C. Rice · Bethesda, US
• Mariena V. Mattson · Rockville, US
• Arthur E. Jacobson · Rockville, US

Key dates

• Filing date: Jan 29, 1992
• Grant date: Mar 23, 1993
• Expiry date: Jan 29, 2012

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D451/00
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

This invention is in the field of clinical neurology and relates specifically to compounds, compositions and methods for treatment of patients with generalized epilepsy or partial (symptomatic) epilepsy using compounds of the formula: ##STR1## This invention also relates to compounds, compositions and methods of treatment for drug craving in patients addicted to cocaine.