Certain indole compounds which inhibit EGF receptor tyrosine kinase

US5196446A · kind A · utility

Assignee

• YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. · IL

Inventors

• Alexander Levitzki · Melrose, US
• Chaim Gilon · Jerusalem, IL
• Aviv Gazit · Jerusalem, IL

Key dates

• Filing date: Apr 16, 1991
• Grant date: Mar 23, 1993
• Expiry date: Apr 16, 2011

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D317/62
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Heteroarylethenediyl compounds wherein the heteroaryl group can be mono- or icyclic heteroaryl and the aryl group can be or mono- or bicyclic carbocyclic, said compound optionally substituted or polysubstituted, with the proviso that the heteroaryl group is not furyl or thienyl when the ethenediyl group has geminal cyano substituents, and pharmaceutical compositions comprising said compounds, and the use thereof for inhibiting a protein tyrosine kinase portion of a receptor selected from epidermal growth factor and platelet derived growth factor in a patient suffering from such disorder.